Drug interactions
Bcg vaccine live + Procarbazine
Severity: Contraindicated
Bcg vaccine live and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine suppresses immune function and bone marrow. Live BCG given to an immunosuppressed patient carries a risk of disseminated BCG infection, and the protective response is likely to be reduced.
What this interaction means in plain words
Bcg vaccine live and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression allows unchecked replication of live attenuated mycobacteria and weakens vaccine response.
What to do
Do not give live BCG during procarbazine treatment. Delay vaccination until immune function has recovered, generally at least 3 months after chemotherapy ends.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Buspirone + Procarbazine Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Procarbazine?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine suppresses immune function and bone marrow. Live BCG given to an immunosuppressed patient carries a risk of disseminated BCG infection, and the protective response is likely to be reduced.
How serious is the interaction between Bcg vaccine live and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live BCG during procarbazine treatment. Delay vaccination until immune function has recovered, generally at least 3 months after chemotherapy ends.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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