Drug reference
procarbazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Alkylating Agents)
Mechanism of action
Methylhydrazine derivative; inhibits protein, DNA, RNA synthesis; may suppress mitosis and damage DNA directly
Common side effects
- neuropathy
- neurotoxicity
- Pleural effusion
- Impairment of fertility
Boxed warnings
- The therapy should be given only by or under the supervision of a physician experienced in the use of potent antineoplastic drugs Adequate clinical and laboratory facilities should be available to patients for proper monitoring of treatment
Known interactions (24)
- amitriptyline + procarbazine Contraindicated
- atomoxetine + procarbazine Contraindicated
- brimonidine + procarbazine Contraindicated
- buspirone + procarbazine Contraindicated
- carbamazepine + procarbazine Contraindicated
- citalopram + procarbazine Contraindicated
- clomipramine + procarbazine Contraindicated
- duloxetine + procarbazine Contraindicated
- escitalopram + procarbazine Contraindicated
- almotriptan + procarbazine Major
- carbidopa-entacapone-levodopa + procarbazine Major
- carbidopa-levodopa + procarbazine Major
- cyproheptadine + procarbazine Major
- desipramine + procarbazine Major
- desvenlafaxine + procarbazine Major
- dextroamphetamine + procarbazine Major
- dextromethorphan + procarbazine Major
- fluoxetine + procarbazine Major
- fluvoxamine + procarbazine Major
- imipramine + procarbazine Major
- isocarboxazid + procarbazine Major
- procarbazine + sertraline Major
- caffeine + procarbazine Moderate
- isoproterenol + procarbazine Moderate
Related conditions
Frequently asked questions
What drug class is procarbazine?
procarbazine belongs to: Oncology.
How does procarbazine work?
Methylhydrazine derivative; inhibits protein, DNA, RNA synthesis; may suppress mitosis and damage DNA directly
What are the common side effects of procarbazine?
neuropathy, neurotoxicity, Pleural effusion, Impairment of fertility
Which drugs interact with procarbazine?
amitriptyline, atomoxetine, brimonidine, buspirone, carbamazepine, citalopram, clomipramine, duloxetine, escitalopram, almotriptan, carbidopa-entacapone-levodopa, carbidopa-levodopa, cyproheptadine, desipramine, desvenlafaxine
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