Drug interactions
Bcg vaccine live + Streptomycin
Severity: Moderate
Bcg vaccine live and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptomycin is active against Mycobacterium species and could reduce the viability of live BCG, lowering the immune response. Patients on antimycobacterial therapy generally should not be vaccinated with BCG until treatment is finished.
What this interaction means in plain words
Bcg vaccine live and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antimycobacterial activity inhibits the live attenuated BCG organism, reducing its replication and immunogenicity.
What to do
Defer BCG vaccination until streptomycin therapy is complete and reassess the need for vaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Bcg vaccine live with Streptomycin?
MediHelp rates the interaction as moderate. Bcg vaccine live and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is active against Mycobacterium species and could reduce the viability of live BCG, lowering the immune response. Patients on antimycobacterial therapy generally should not be vaccinated with BCG until treatment is finished.
How serious is the interaction between Bcg vaccine live and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer BCG vaccination until streptomycin therapy is complete and reassess the need for vaccination.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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