Drug interactions
Belimumab + Hepatitis A vaccine inactivated
Severity: Moderate
Belimumab and Hepatitis A vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belimumab reduces B-cell survival and may weaken antibody responses to vaccines. Hepatitis A vaccine is not live so it is safe to give, but protection may be lower.
What this interaction means in plain words
Belimumab and Hepatitis A vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belimumab belongs to Miscellaneous; Hepatitis A vaccine inactivated belongs to Anti Virals.
Why it happens
BLyS inhibition by belimumab reduces B-cell survival and differentiation, which can impair vaccine antibody production.
What to do
Vaccinate at least 2 weeks before starting belimumab when possible. If vaccinated during therapy, check anti-HAV antibody levels and consider revaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Other interactions of Belimumab
- Belimumab + Measles mumps and rubella vaccine Major
- Abatacept + Belimumab Moderate
- Adalimumab + Belimumab Moderate
- Anakinra + Belimumab Moderate
- Anti-thymocyte + Belimumab Moderate
- Belimumab + Denosumab Moderate
Frequently asked questions
Can I take Belimumab with Hepatitis A vaccine inactivated?
MediHelp rates the interaction as moderate. Belimumab and Hepatitis A vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belimumab reduces B-cell survival and may weaken antibody responses to vaccines. Hepatitis A vaccine is not live so it is safe to give, but protection may be lower.
How serious is the interaction between Belimumab and Hepatitis A vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting belimumab when possible. If vaccinated during therapy, check anti-HAV antibody levels and consider revaccination.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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