Drug interactions
Belladonna alkaloids + Fesoterodine
Severity: Moderate
Belladonna alkaloids and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids are antimuscarinic and combined use with fesoterodine increases anticholinergic effects including dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Belladonna alkaloids and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid duplicate antimuscarinic therapy where possible; otherwise monitor for anticholinergic toxicity and reduce doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belladonna alkaloids and Fesoterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fesoterodine
Frequently asked questions
Can I take Belladonna alkaloids with Fesoterodine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids are antimuscarinic and combined use with fesoterodine increases anticholinergic effects including dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Belladonna alkaloids and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antimuscarinic therapy where possible; otherwise monitor for anticholinergic toxicity and reduce doses.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
