Drug interactions
Belladonna alkaloids + Imipramine
Severity: Moderate
Belladonna alkaloids and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids are antimuscarinic agents and add to the strong anticholinergic burden of imipramine. This can cause dry mouth, constipation, urinary retention, tachycardia, blurred vision, hyperthermia and confusion.
What this interaction means in plain words
Belladonna alkaloids and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity, especially in older patients, and reduce the dose or choose a non-anticholinergic alternative if symptoms occur. Avoid in narrow-angle glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Belladonna alkaloids with Imipramine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids are antimuscarinic agents and add to the strong anticholinergic burden of imipramine. This can cause dry mouth, constipation, urinary retention, tachycardia, blurred vision, hyperthermia and confusion.
How serious is the interaction between Belladonna alkaloids and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients, and reduce the dose or choose a non-anticholinergic alternative if symptoms occur. Avoid in narrow-angle glaucoma or urinary obstruction.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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