Drug interactions
Belladonna alkaloids + Scopolamine
Severity: Moderate
Belladonna alkaloids and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids include atropine and hyoscyamine, which have the same antimuscarinic action as scopolamine. Combined use can cause additive anticholinergic toxicity with dry mouth, tachycardia, urinary retention, constipation, confusion and hyperthermia.
What this interaction means in plain words
Belladonna alkaloids and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid concurrent use where possible, and monitor for anticholinergic toxicity, especially in elderly patients and children.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Belladonna alkaloids with Scopolamine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids include atropine and hyoscyamine, which have the same antimuscarinic action as scopolamine. Combined use can cause additive anticholinergic toxicity with dry mouth, tachycardia, urinary retention, constipation, confusion and hyperthermia.
How serious is the interaction between Belladonna alkaloids and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, and monitor for anticholinergic toxicity, especially in elderly patients and children.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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