Drug interactions
Benzhydrocodone / acetaminophen + Scopolamine
Severity: Major
Benzhydrocodone / acetaminophen and Scopolamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine can cause drowsiness and dizziness, and benzhydrocodone is an opioid that causes sedation and respiratory depression. Together they can produce additive CNS depression, with greater risk of profound sedation, impaired psychomotor performance and breathing problems.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system depression from opioid agonism and central antimuscarinic effects.
What to do
Reserve the combination for patients without adequate alternatives, using the lowest effective doses for the shortest time. Monitor for sedation and respiratory depression and counsel patients to avoid driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Scopolamine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Scopolamine can cause drowsiness and dizziness, and benzhydrocodone is an opioid that causes sedation and respiratory depression. Together they can produce additive CNS depression, with greater risk of profound sedation, impaired psychomotor performance and breathing problems.
How serious is the interaction between Benzhydrocodone / acetaminophen and Scopolamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives, using the lowest effective doses for the shortest time. Monitor for sedation and respiratory depression and counsel patients to avoid driving.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Buprenorphine long-acting, Buprenorphine subdermal implant, Buprenorphine transdermal. The full list is on the Scopolamine page.
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