Drug interactions
Belladonna and opium + Chlordiazepoxide-clidinium
Severity: Major
Belladonna and opium and Chlordiazepoxide-clidinium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium contains opioids that combined with a benzodiazepine increase risk of profound sedation, respiratory depression and death. Belladonna also adds anticholinergic effects to clidinium.
What this interaction means in plain words
Belladonna and opium and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression plus additive anticholinergic effects.
What to do
Avoid combining where possible; otherwise use minimum doses and monitor respiratory status and sedation closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
- Buprenorphine buccal + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Belladonna and opium with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Belladonna and opium and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium contains opioids that combined with a benzodiazepine increase risk of profound sedation, respiratory depression and death. Belladonna also adds anticholinergic effects to clidinium.
How serious is the interaction between Belladonna and opium and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; otherwise use minimum doses and monitor respiratory status and sedation closely.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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