Drug interactions
Amobarbital + Chlordiazepoxide-clidinium
Severity: Major
Amobarbital and Chlordiazepoxide-clidinium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and benzodiazepines together produce additive CNS and respiratory depression. Amobarbital also induces CYP3A4 and may lower chlordiazepoxide levels, making the net effect unpredictable.
What this interaction means in plain words
Amobarbital and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Why it happens
Additive GABAergic CNS depression, with CYP3A4 induction by amobarbital altering chlordiazepoxide clearance.
What to do
Avoid the combination where possible. If used, give reduced doses and monitor sedation and respiratory status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
- Buprenorphine buccal + Chlordiazepoxide-clidinium Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Amobarbital and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce additive CNS and respiratory depression. Amobarbital also induces CYP3A4 and may lower chlordiazepoxide levels, making the net effect unpredictable.
How serious is the interaction between Amobarbital and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, give reduced doses and monitor sedation and respiratory status.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.
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