Drug interactions
Brexanolone + Cyproheptadine
Severity: Major
Brexanolone and Cyproheptadine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness in some patients. Added sedative antihistamine therapy may increase this risk.
What this interaction means in plain words
Brexanolone and Cyproheptadine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression through GABA-A positive modulation by brexanolone and H1 antagonism by cyproheptadine.
What to do
Hold or avoid cyproheptadine during the infusion where possible, and continue continuous pulse oximetry and sedation monitoring. Interrupt the infusion if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Brexanolone with Cyproheptadine?
MediHelp rates the interaction as major. Brexanolone and Cyproheptadine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness in some patients. Added sedative antihistamine therapy may increase this risk.
How serious is the interaction between Brexanolone and Cyproheptadine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold or avoid cyproheptadine during the infusion where possible, and continue continuous pulse oximetry and sedation monitoring. Interrupt the infusion if excessive sedation occurs.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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