Drug interactions
Belladonna and opium + Fesoterodine
Severity: Moderate
Belladonna and opium and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The belladonna component adds antimuscarinic effects to fesoterodine, and opium slows gut motility, so constipation, urinary retention and ileus risk are increased. Opioid-related sedation may add to central effects.
What this interaction means in plain words
Belladonna and opium and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects with opioid-induced reduction of gastrointestinal and bladder motility.
What to do
Monitor for urinary retention, constipation and sedation, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Belladonna and opium with Fesoterodine?
MediHelp rates the interaction as moderate. Belladonna and opium and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The belladonna component adds antimuscarinic effects to fesoterodine, and opium slows gut motility, so constipation, urinary retention and ileus risk are increased. Opioid-related sedation may add to central effects.
How serious is the interaction between Belladonna and opium and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and sedation, and use the lowest effective doses.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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