Drug interactions
Belladonna and opium + Isocarboxazid
Severity: Major
Belladonna and opium and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component can interact with a nonselective MAOI to cause serotonin-like toxicity or exaggerated CNS and respiratory depression with hypotension. The belladonna anticholinergic effects may also be intensified by MAOIs.
What this interaction means in plain words
Belladonna and opium and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may potentiate opioid and serotonergic effects and prolong anticholinergic effects; the exact mechanism is not fully established.
What to do
Avoid the combination, and wait 14 days after stopping isocarboxazid before using belladonna and opium. Choose an alternative agent and monitor vital signs and mental status if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Isocarboxazid?
MediHelp rates the interaction as major. Belladonna and opium and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component can interact with a nonselective MAOI to cause serotonin-like toxicity or exaggerated CNS and respiratory depression with hypotension. The belladonna anticholinergic effects may also be intensified by MAOIs.
How serious is the interaction between Belladonna and opium and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and wait 14 days after stopping isocarboxazid before using belladonna and opium. Choose an alternative agent and monitor vital signs and mental status if unavoidable.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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