Drug interactions
Apraclonidine + Isocarboxazid
Severity: Contraindicated
Apraclonidine and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.
What this interaction means in plain words
Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apraclonidine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Why it happens
Mechanism is not firmly established; MAO inhibition may alter catecholamine metabolism and potentiate the systemic effects of the alpha-2 agonist.
What to do
Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apraclonidine and Isocarboxazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
- Benzphetamine + Isocarboxazid Contraindicated
Other interactions of Apraclonidine
Frequently asked questions
Can I take Apraclonidine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.
How serious is the interaction between Apraclonidine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
