Drug interactions
Belladonna and opium + Lidocaine
Severity: Minor
Belladonna and opium and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component is an opioid that causes sedation and respiratory depression, and systemic lidocaine can add to CNS depression. Anticholinergic belladonna adds to confusion in susceptible patients. The risk is mainly with intravenous lidocaine.
What this interaction means in plain words
Belladonna and opium and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive central nervous system depression from systemic lidocaine and opioid.
What to do
Monitor sedation and breathing when systemic lidocaine is given with this product. No action is needed for topical or local use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Belladonna and opium with Lidocaine?
MediHelp rates the interaction as minor. Belladonna and opium and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The opium component is an opioid that causes sedation and respiratory depression, and systemic lidocaine can add to CNS depression. Anticholinergic belladonna adds to confusion in susceptible patients. The risk is mainly with intravenous lidocaine.
How serious is the interaction between Belladonna and opium and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and breathing when systemic lidocaine is given with this product. No action is needed for topical or local use.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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