Drug interactions
Belladonna and opium + Lofexidine
Severity: Moderate
Belladonna and opium and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds CNS and respiratory depression to the sedative and hypotensive effects of lofexidine. Excessive sedation and bradycardia may result.
What this interaction means in plain words
Belladonna and opium and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid action and central alpha-2 agonism.
What to do
Monitor sedation, respiratory rate and blood pressure, and use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Belladonna and opium with Lofexidine?
MediHelp rates the interaction as moderate. Belladonna and opium and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component adds CNS and respiratory depression to the sedative and hypotensive effects of lofexidine. Excessive sedation and bradycardia may result.
How serious is the interaction between Belladonna and opium and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, and use the lowest effective opioid dose.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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