Drug interactions
Belladonna and opium + Metaxalone
Severity: Major
Belladonna and opium and Metaxalone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component can cause respiratory depression and profound sedation when combined with other CNS depressants. Metaxalone increases this risk.
What this interaction means in plain words
Belladonna and opium and Metaxalone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from an opioid and a muscle relaxant.
What to do
Avoid the combination where possible; otherwise use the lowest effective doses for the shortest duration. Monitor for sedation and slowed breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belladonna and opium and Metaxalone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Metaxalone
Frequently asked questions
Can I take Belladonna and opium with Metaxalone?
MediHelp rates the interaction as major. Belladonna and opium and Metaxalone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component can cause respiratory depression and profound sedation when combined with other CNS depressants. Metaxalone increases this risk.
How serious is the interaction between Belladonna and opium and Metaxalone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; otherwise use the lowest effective doses for the shortest duration. Monitor for sedation and slowed breathing.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Metaxalone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
