Drug interactions
Belladonna and opium + Oxybutynin
Severity: Moderate
Belladonna and opium and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna adds antimuscarinic effects to oxybutynin, and opium can further slow gut motility, raising the risk of constipation, urinary retention and ileus. CNS effects may also be additive.
What this interaction means in plain words
Belladonna and opium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects plus opioid-related reduction in gastrointestinal and bladder motility.
What to do
Monitor bowel and bladder function and sedation; reduce doses or choose an alternative if retention or ileus signs occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Frequently asked questions
Can I take Belladonna and opium with Oxybutynin?
MediHelp rates the interaction as moderate. Belladonna and opium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna adds antimuscarinic effects to oxybutynin, and opium can further slow gut motility, raising the risk of constipation, urinary retention and ileus. CNS effects may also be additive.
How serious is the interaction between Belladonna and opium and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel and bladder function and sedation; reduce doses or choose an alternative if retention or ileus signs occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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