Drug interactions
Bethanechol + Oxybutynin
Severity: Major
Bethanechol and Oxybutynin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is an antimuscarinic bladder relaxant that directly opposes bethanechol's detrusor stimulation, so the therapeutic effect of each is reduced.
What this interaction means in plain words
Bethanechol and Oxybutynin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bethanechol belongs to Gastrointestinal Tract; Oxybutynin belongs to Genitourinary.
Why it happens
Competitive muscarinic antagonism by oxybutynin against bethanechol agonism.
What to do
Avoid combining; reassess the bladder indication and use only one agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
- Amoxapine + Bethanechol Moderate
Other interactions of Oxybutynin
- Clozapine + Oxybutynin Major
- Oxybutynin + Potassium chloride Major
- Oxybutynin + Rivastigmine Major
- Oxybutynin + Trihexyphenidyl Major
- Abobotulinumtoxina + Oxybutynin Moderate
- Aclidinium + Oxybutynin Moderate
Frequently asked questions
Can I take Bethanechol with Oxybutynin?
MediHelp rates the interaction as major. Bethanechol and Oxybutynin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybutynin is an antimuscarinic bladder relaxant that directly opposes bethanechol's detrusor stimulation, so the therapeutic effect of each is reduced.
How serious is the interaction between Bethanechol and Oxybutynin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; reassess the bladder indication and use only one agent.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Physostigmine. The full list is on the Bethanechol page.
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