Drug interactions
Belladonna and opium + Scopolamine
Severity: Moderate
Belladonna and opium and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium combines antimuscarinic alkaloids with an opioid, so adding scopolamine increases anticholinergic effects and can cause urinary retention, constipation or ileus, confusion and sedation. Opium also adds CNS and respiratory depression.
What this interaction means in plain words
Belladonna and opium and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with added opioid-related CNS depression and reduced gut motility.
What to do
Monitor for urinary retention, constipation, sedation and confusion, and avoid the combination in elderly patients or those with obstruction or glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Belladonna and opium with Scopolamine?
MediHelp rates the interaction as moderate. Belladonna and opium and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna and opium combines antimuscarinic alkaloids with an opioid, so adding scopolamine increases anticholinergic effects and can cause urinary retention, constipation or ileus, confusion and sedation. Opium also adds CNS and respiratory depression.
How serious is the interaction between Belladonna and opium and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, sedation and confusion, and avoid the combination in elderly patients or those with obstruction or glaucoma.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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