Drug interactions
Belladonna and opium + Tolterodine
Severity: Moderate
Belladonna and opium and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium combines an antimuscarinic with an opioid, so use with tolterodine may add anticholinergic effects and increase the risk of constipation, urinary retention and ileus. Opioid-related sedation may also add to central effects.
What this interaction means in plain words
Belladonna and opium and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic blockade, with opioid effects further reducing gut motility and bladder emptying.
What to do
Monitor bowel function, urinary retention and sedation. Avoid the combination in patients with urinary obstruction or ileus risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Belladonna and opium with Tolterodine?
MediHelp rates the interaction as moderate. Belladonna and opium and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna and opium combines an antimuscarinic with an opioid, so use with tolterodine may add anticholinergic effects and increase the risk of constipation, urinary retention and ileus. Opioid-related sedation may also add to central effects.
How serious is the interaction between Belladonna and opium and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary retention and sedation. Avoid the combination in patients with urinary obstruction or ileus risk.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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