Drug interactions
Belzutifan + Buprenorphine
Severity: Moderate
Belzutifan and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower buprenorphine exposure. This could reduce analgesia or lead to opioid withdrawal symptoms in patients on maintenance therapy.
What this interaction means in plain words
Belzutifan and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Buprenorphine belongs to Musculoskeletal.
Why it happens
Belzutifan induction of CYP3A4 increases buprenorphine clearance.
What to do
Monitor for withdrawal symptoms or loss of analgesic effect and increase the buprenorphine dose if needed. Reassess the dose if belzutifan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Buprenorphine?
MediHelp rates the interaction as moderate. Belzutifan and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower buprenorphine exposure. This could reduce analgesia or lead to opioid withdrawal symptoms in patients on maintenance therapy.
How serious is the interaction between Belzutifan and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or loss of analgesic effect and increase the buprenorphine dose if needed. Reassess the dose if belzutifan is stopped.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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