Drug interactions
Belzutifan + Cyclosporin
Severity: Major
Belzutifan and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces UGT2B17 and CYP3A4 and can lower exposure to sensitive CYP3A4 substrates such as cyclosporine. Reduced cyclosporine levels may lead to subtherapeutic immunosuppression and a risk of rejection or graft-versus-host disease.
What this interaction means in plain words
Belzutifan and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Belzutifan belongs to Miscellaneous; Cyclosporin belongs to Miscellaneous.
Why it happens
Belzutifan induces CYP3A4, increasing cyclosporine metabolism and lowering its blood concentrations.
What to do
Monitor cyclosporine trough concentrations closely when starting or stopping belzutifan and adjust the dose as needed. Consider an alternative to belzutifan if levels cannot be maintained.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Cyclosporin?
MediHelp rates the interaction as major. Belzutifan and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belzutifan induces UGT2B17 and CYP3A4 and can lower exposure to sensitive CYP3A4 substrates such as cyclosporine. Reduced cyclosporine levels may lead to subtherapeutic immunosuppression and a risk of rejection or graft-versus-host disease.
How serious is the interaction between Belzutifan and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations closely when starting or stopping belzutifan and adjust the dose as needed. Consider an alternative to belzutifan if levels cannot be maintained.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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