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Drug interactions

Belzutifan + Citalopram

Severity: Minor

Belzutifan and Citalopram: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Belzutifan is a weak CYP3A4 inducer and may modestly reduce citalopram exposure. This could reduce antidepressant effect, although citalopram is cleared by several pathways, so the impact is likely small.

What this interaction means in plain words

Belzutifan and Citalopram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Belzutifan belongs to Miscellaneous; Citalopram belongs to Central Nervous System.

Evidence level: Low

Why it happens

Belzutifan induction of CYP3A4 increases citalopram metabolism.

What to do

Monitor for loss of antidepressant response and adjust the citalopram dose if clinically needed.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Belzutifan with Citalopram?

MediHelp rates the interaction as minor. Belzutifan and Citalopram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belzutifan is a weak CYP3A4 inducer and may modestly reduce citalopram exposure. This could reduce antidepressant effect, although citalopram is cleared by several pathways, so the impact is likely small.

How serious is the interaction between Belzutifan and Citalopram?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and adjust the citalopram dose if clinically needed.

What other medicines interact with Citalopram?

MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.

Full monographs, dosing and an interaction checker in the MediHelp app

Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.

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