Drug interactions
Belzutifan + Diltiazem
Severity: Moderate
Belzutifan and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower diltiazem concentrations. This could reduce blood pressure or rate control.
What this interaction means in plain words
Belzutifan and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Diltiazem belongs to Cardiovascular.
Why it happens
Belzutifan induces CYP3A4, increasing diltiazem metabolism and reducing exposure.
What to do
Monitor heart rate and blood pressure and increase the diltiazem dose if response is inadequate. Reassess dose when belzutifan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belzutifan and Diltiazem, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Diltiazem?
MediHelp rates the interaction as moderate. Belzutifan and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower diltiazem concentrations. This could reduce blood pressure or rate control.
How serious is the interaction between Belzutifan and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and increase the diltiazem dose if response is inadequate. Reassess dose when belzutifan is stopped.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
