Drug interactions
Belzutifan + Isoniazid
Severity: Moderate
Belzutifan and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP2C19, which participates in belzutifan metabolism along with UGT2B17. Higher belzutifan exposure may worsen anemia and hypoxia.
What this interaction means in plain words
Belzutifan and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP2C19, reducing belzutifan clearance.
What to do
Monitor hemoglobin and oxygen saturation, and reduce the belzutifan dose if anemia or hypoxia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Isoniazid?
MediHelp rates the interaction as moderate. Belzutifan and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP2C19, which participates in belzutifan metabolism along with UGT2B17. Higher belzutifan exposure may worsen anemia and hypoxia.
How serious is the interaction between Belzutifan and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation, and reduce the belzutifan dose if anemia or hypoxia develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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