Drug interactions
Bendamustine + Berotralstat
Severity: Minor
Bendamustine and Berotralstat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and bendamustine may be a P-gp substrate. Exposure to bendamustine could be slightly increased, but the clinical significance is uncertain.
What this interaction means in plain words
Bendamustine and Berotralstat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Berotralstat belongs to Miscellaneous.
Why it happens
Inhibition of P-gp efflux may raise bendamustine concentrations.
What to do
No dose change is usually needed; monitor blood counts as routinely done during bendamustine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendamustine and Berotralstat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bendamustine
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Bendamustine with Berotralstat?
MediHelp rates the interaction as minor. Bendamustine and Berotralstat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein, and bendamustine may be a P-gp substrate. Exposure to bendamustine could be slightly increased, but the clinical significance is uncertain.
How serious is the interaction between Bendamustine and Berotralstat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood counts as routinely done during bendamustine therapy.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
