Drug interactions
Berotralstat + Nilotinib
Severity: Major
Berotralstat and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and can raise concentrations of nilotinib, which is a P-gp substrate. It also inhibits CYP3A4 and prolongs QT at higher doses, so nilotinib toxicity including QT prolongation may increase.
What this interaction means in plain words
Berotralstat and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Berotralstat belongs to Miscellaneous; Nilotinib belongs to Oncology.
Why it happens
Inhibition of P-gp and CYP3A4 by berotralstat increases nilotinib exposure, with additive QT effects.
What to do
Obtain a baseline ECG and monitor it, along with electrolytes, during coadministration. Consider an alternative HAE prophylaxis if QTc increases.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Berotralstat
Frequently asked questions
Can I take Berotralstat with Nilotinib?
MediHelp rates the interaction as major. Berotralstat and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits P-glycoprotein and can raise concentrations of nilotinib, which is a P-gp substrate. It also inhibits CYP3A4 and prolongs QT at higher doses, so nilotinib toxicity including QT prolongation may increase.
How serious is the interaction between Berotralstat and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it, along with electrolytes, during coadministration. Consider an alternative HAE prophylaxis if QTc increases.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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