Drug interactions
Bendamustine + Sotorasib
Severity: Minor
Bendamustine and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak inducer of CYP3A4 and a P-gp inhibitor. Bendamustine is not a clearly important P-gp substrate and is cleared mainly by hydrolysis, so a clinically meaningful change is unlikely.
What this interaction means in plain words
Bendamustine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Possible P-gp modulation by sotorasib; clinical relevance for bendamustine is unestablished.
What to do
No specific action is needed beyond routine monitoring of blood counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bendamustine
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Bendamustine with Sotorasib?
MediHelp rates the interaction as minor. Bendamustine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a weak inducer of CYP3A4 and a P-gp inhibitor. Bendamustine is not a clearly important P-gp substrate and is cleared mainly by hydrolysis, so a clinically meaningful change is unlikely.
How serious is the interaction between Bendamustine and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of blood counts.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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