Drug interactions
Colchicine + Sotorasib
Severity: Major
Colchicine and Sotorasib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is reported to inhibit P-glycoprotein, which would raise rather than lower colchicine exposure. Higher colchicine levels increase the risk of gastrointestinal, hematologic and neuromuscular toxicity.
What this interaction means in plain words
Colchicine and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-glycoprotein, reducing colchicine efflux and increasing exposure.
What to do
Avoid the combination if possible, or reduce the colchicine dose and monitor for toxicity. Be especially cautious in renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
- Efavirenz + Sotorasib Major
Frequently asked questions
Can I take Colchicine with Sotorasib?
MediHelp rates the interaction as major. Colchicine and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotorasib is reported to inhibit P-glycoprotein, which would raise rather than lower colchicine exposure. Higher colchicine levels increase the risk of gastrointestinal, hematologic and neuromuscular toxicity.
How serious is the interaction between Colchicine and Sotorasib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or reduce the colchicine dose and monitor for toxicity. Be especially cautious in renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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