Drug interactions
Bendroflumethiazide + Canagliflozin-metformin
Severity: Moderate
Bendroflumethiazide and Canagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of antidiabetic therapy. Thiazides can also cause volume depletion, which may be relevant to canagliflozin because of its diuretic effect and to renal function with metformin.
What this interaction means in plain words
Bendroflumethiazide and Canagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides impair insulin secretion and glucose tolerance (partly via hypokalemia), opposing antidiabetic effects; additive volume depletion also occurs with SGLT2 inhibition.
What to do
Monitor blood glucose, renal function, electrolytes and volume status, and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Bendroflumethiazide with Canagliflozin-metformin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Canagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of antidiabetic therapy. Thiazides can also cause volume depletion, which may be relevant to canagliflozin because of its diuretic effect and to renal function with metformin.
How serious is the interaction between Bendroflumethiazide and Canagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, renal function, electrolytes and volume status, and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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