Drug interactions
Bendroflumethiazide + Chlorpropamide
Severity: Moderate
Bendroflumethiazide and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and impair glycemic control, particularly at higher doses, offsetting the effect of chlorpropamide. Thiazides can also cause hyponatremia, and chlorpropamide may cause SIADH-like effects, so sodium may fall further.
What this interaction means in plain words
Bendroflumethiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism via thiazide-induced hypokalemia and reduced insulin secretion and sensitivity.
What to do
Monitor blood glucose and sodium after starting the thiazide. Increase the antidiabetic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Bendroflumethiazide with Chlorpropamide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and impair glycemic control, particularly at higher doses, offsetting the effect of chlorpropamide. Thiazides can also cause hyponatremia, and chlorpropamide may cause SIADH-like effects, so sodium may fall further.
How serious is the interaction between Bendroflumethiazide and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and sodium after starting the thiazide. Increase the antidiabetic dose if needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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