Drug interactions
Bendroflumethiazide + Chlorthalidone
Severity: Moderate
Bendroflumethiazide and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are thiazide-type diuretics, so combining them duplicates therapy and increases the risk of hypokalemia, hyponatremia, volume depletion and hypotension.
What this interaction means in plain words
Bendroflumethiazide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of distal tubular sodium-chloride reabsorption with increased potassium and sodium loss.
What to do
Avoid using two thiazide-type diuretics together unless intended, and monitor electrolytes and renal function if they are combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Bendroflumethiazide with Chlorthalidone?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are thiazide-type diuretics, so combining them duplicates therapy and increases the risk of hypokalemia, hyponatremia, volume depletion and hypotension.
How serious is the interaction between Bendroflumethiazide and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together unless intended, and monitor electrolytes and renal function if they are combined.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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