Drug interactions
Bendroflumethiazide + Empagliflozin-metformin
Severity: Moderate
Bendroflumethiazide and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin and thiazide diuretics both promote fluid loss, so combined use can cause volume depletion, hypotension and dehydration. Thiazides may also raise blood glucose slightly. Risk is greater in older adults and those with renal impairment.
What this interaction means in plain words
Bendroflumethiazide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive diuretic and natriuretic effects.
What to do
Monitor volume status, blood pressure, electrolytes and renal function; consider reducing the diuretic dose if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Bendroflumethiazide with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin and thiazide diuretics both promote fluid loss, so combined use can cause volume depletion, hypotension and dehydration. Thiazides may also raise blood glucose slightly. Risk is greater in older adults and those with renal impairment.
How serious is the interaction between Bendroflumethiazide and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor volume status, blood pressure, electrolytes and renal function; consider reducing the diuretic dose if volume depletion develops.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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