Drug interactions
Bendroflumethiazide + Eprosartan-hydrochlorothiazide
Severity: Moderate
Bendroflumethiazide and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension, hyperuricemia and renal impairment, with limited added benefit.
What this interaction means in plain words
Bendroflumethiazide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the sodium-chloride cotransporter in the distal tubule, leading to greater electrolyte loss and volume depletion.
What to do
Avoid concurrent use of two thiazide-type diuretics and stop the duplicate agent. If both have been taken, check electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendroflumethiazide and Eprosartan-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Bendroflumethiazide with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension, hyperuricemia and renal impairment, with limited added benefit.
How serious is the interaction between Bendroflumethiazide and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazide-type diuretics and stop the duplicate agent. If both have been taken, check electrolytes and renal function.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
