Drug interactions
Bendroflumethiazide + Fludrocortisone
Severity: Moderate
Bendroflumethiazide and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone increases renal potassium excretion and thiazide diuretics do the same, so combined use can produce significant hypokalemia. Hypokalemia may cause arrhythmias and muscle weakness, particularly in patients on digoxin or with heart disease.
What this interaction means in plain words
Bendroflumethiazide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive kaliuresis from mineralocorticoid activity and increased distal sodium delivery caused by thiazide diuresis.
What to do
Check serum potassium and blood pressure periodically and supplement potassium or adjust doses if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Bendroflumethiazide with Fludrocortisone?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone increases renal potassium excretion and thiazide diuretics do the same, so combined use can produce significant hypokalemia. Hypokalemia may cause arrhythmias and muscle weakness, particularly in patients on digoxin or with heart disease.
How serious is the interaction between Bendroflumethiazide and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and blood pressure periodically and supplement potassium or adjust doses if levels fall.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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