Drug interactions
Bendroflumethiazide + Fluticasone-salmeterol
Severity: Moderate
Bendroflumethiazide and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics lower serum potassium, and beta-2 agonists can further lower it by shifting potassium into cells. Combined use may cause significant hypokalemia and raise arrhythmia risk, particularly with higher salmeterol doses or hypoxia.
What this interaction means in plain words
Bendroflumethiazide and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from renal potassium loss (thiazide) and intracellular shift (beta-2 agonist).
What to do
Monitor serum potassium periodically, especially at initiation or dose increases. Replace potassium or add a potassium-sparing agent if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Bendroflumethiazide with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics lower serum potassium, and beta-2 agonists can further lower it by shifting potassium into cells. Combined use may cause significant hypokalemia and raise arrhythmia risk, particularly with higher salmeterol doses or hypoxia.
How serious is the interaction between Bendroflumethiazide and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially at initiation or dose increases. Replace potassium or add a potassium-sparing agent if low.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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