Drug interactions
Bendroflumethiazide + Gliclazide
Severity: Minor
Bendroflumethiazide and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may reduce the glucose-lowering effect of sulfonylureas such as gliclazide. Loss of glycaemic control is more likely at higher thiazide doses or in patients with marginal control.
What this interaction means in plain words
Bendroflumethiazide and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides cause hypokalaemia and reduced insulin secretion and may impair peripheral insulin sensitivity, opposing the sulfonylurea effect.
What to do
Monitor blood glucose and HbA1c when starting or adjusting the thiazide, and increase the antidiabetic dose if control deteriorates. Check potassium and correct hypokalaemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendroflumethiazide and Gliclazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Frequently asked questions
Can I take Bendroflumethiazide with Gliclazide?
MediHelp rates the interaction as minor. Bendroflumethiazide and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may reduce the glucose-lowering effect of sulfonylureas such as gliclazide. Loss of glycaemic control is more likely at higher thiazide doses or in patients with marginal control.
How serious is the interaction between Bendroflumethiazide and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting the thiazide, and increase the antidiabetic dose if control deteriorates. Check potassium and correct hypokalaemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
