Drug interactions
Bendroflumethiazide + Glipizide-metformin
Severity: Minor
Bendroflumethiazide and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can impair glucose tolerance and raise blood glucose, partly opposing the effect of antidiabetic drugs. The effect is dose-related and usually modest at low doses.
What this interaction means in plain words
Bendroflumethiazide and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity raise blood glucose.
What to do
Monitor blood glucose and potassium after starting or increasing the thiazide, and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Bendroflumethiazide with Glipizide-metformin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can impair glucose tolerance and raise blood glucose, partly opposing the effect of antidiabetic drugs. The effect is dose-related and usually modest at low doses.
How serious is the interaction between Bendroflumethiazide and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting or increasing the thiazide, and adjust antidiabetic therapy if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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