Drug interactions
Dichlorphenamide + Glipizide-metformin
Severity: Major
Dichlorphenamide and Glipizide-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be worsened.
What this interaction means in plain words
Dichlorphenamide and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dichlorphenamide belongs to Miscellaneous; Glipizide-metformin belongs to Endocrine.
Why it happens
Additive pharmacodynamic risk of acidosis through carbonic anhydrase inhibition and metformin-related lactate accumulation.
What to do
Monitor serum bicarbonate and electrolytes at baseline and periodically, and reassess the need for metformin if acidosis develops. Avoid the combination in patients with renal impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glipizide-metformin
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Glipizide-metformin?
MediHelp rates the interaction as major. Dichlorphenamide and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be worsened.
How serious is the interaction between Dichlorphenamide and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and electrolytes at baseline and periodically, and reassess the need for metformin if acidosis develops. Avoid the combination in patients with renal impairment.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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