Drug interactions
Bendroflumethiazide + Glyburide-metformin
Severity: Moderate
Bendroflumethiazide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose by impairing insulin secretion and reducing insulin sensitivity, partly through potassium loss. This may reduce the glycemic control achieved with glyburide and metformin, particularly at higher thiazide doses.
What this interaction means in plain words
Bendroflumethiazide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through thiazide-induced hypokalemia, reduced insulin release and increased insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting or changing the thiazide dose and keep potassium in the normal range. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Bendroflumethiazide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose by impairing insulin secretion and reducing insulin sensitivity, partly through potassium loss. This may reduce the glycemic control achieved with glyburide and metformin, particularly at higher thiazide doses.
How serious is the interaction between Bendroflumethiazide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the thiazide dose and keep potassium in the normal range. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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