Drug interactions
Bendroflumethiazide + Hydrochlorothiazide-telmisartan
Severity: Moderate
Bendroflumethiazide and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are thiazide diuretics, so this combination gives duplicate diuretic therapy. It increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and renal impairment, with no meaningful gain in efficacy.
What this interaction means in plain words
Bendroflumethiazide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication with additive inhibition of the sodium-chloride cotransporter in the distal tubule.
What to do
Avoid combining two thiazides; use a single thiazide and adjust its dose. If both have been given, check electrolytes and renal function and stop one.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are thiazide diuretics, so this combination gives duplicate diuretic therapy. It increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and renal impairment, with no meaningful gain in efficacy.
How serious is the interaction between Bendroflumethiazide and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides; use a single thiazide and adjust its dose. If both have been given, check electrolytes and renal function and stop one.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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