Drug interactions
Bendroflumethiazide + Hydrochlorothiazide-valsartan
Severity: Moderate
Bendroflumethiazide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a duplication of thiazide diuretic therapy, as hydrochlorothiazide and bendroflumethiazide have the same effects. Together they increase the risk of hypokalemia, hyponatremia, hypotension, volume depletion and metabolic disturbances without clear added benefit.
What this interaction means in plain words
Bendroflumethiazide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubule sodium-chloride cotransporter with increased urinary loss of potassium, sodium and magnesium.
What to do
Avoid using two thiazides together; use a single agent. If combined, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a duplication of thiazide diuretic therapy, as hydrochlorothiazide and bendroflumethiazide have the same effects. Together they increase the risk of hypokalemia, hyponatremia, hypotension, volume depletion and metabolic disturbances without clear added benefit.
How serious is the interaction between Bendroflumethiazide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together; use a single agent. If combined, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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