Drug interactions
Bendroflumethiazide + Ibuprofen
Severity: Moderate
Bendroflumethiazide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ibuprofen can blunt the diuretic and antihypertensive effects of thiazides. They may also increase the risk of kidney injury, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Bendroflumethiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ibuprofen inhibits renal prostaglandin synthesis, causing sodium and water retention and reducing renal perfusion, which antagonizes thiazide effects.
What to do
Monitor blood pressure, fluid status and renal function if used together, and use the lowest effective ibuprofen dose for the shortest time. Consider paracetamol as an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Bendroflumethiazide with Ibuprofen?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ibuprofen can blunt the diuretic and antihypertensive effects of thiazides. They may also increase the risk of kidney injury, particularly in volume-depleted or elderly patients.
How serious is the interaction between Bendroflumethiazide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function if used together, and use the lowest effective ibuprofen dose for the shortest time. Consider paracetamol as an alternative analgesic.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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