Drug interactions
Bendroflumethiazide + Insulin degludec-liraglutide
Severity: Moderate
Bendroflumethiazide and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and worsen glycemic control in patients with diabetes. Insulin requirements may increase, especially at higher diuretic doses.
What this interaction means in plain words
Bendroflumethiazide and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides reduce insulin sensitivity and secretion, partly through hypokalemia, opposing the glucose-lowering effect.
What to do
Monitor blood glucose and potassium when starting or changing the thiazide dose. Correct hypokalemia and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendroflumethiazide and Insulin degludec-liraglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Bendroflumethiazide with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and worsen glycemic control in patients with diabetes. Insulin requirements may increase, especially at higher diuretic doses.
How serious is the interaction between Bendroflumethiazide and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when starting or changing the thiazide dose. Correct hypokalemia and adjust the insulin dose as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
