Drug interactions
Diazoxide + Insulin degludec-liraglutide
Severity: Major
Diazoxide and Insulin degludec-liraglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide causes hyperglycemia and directly opposes the glucose-lowering effect of insulin and liraglutide. Glycemic control can deteriorate substantially, sometimes with ketoacidosis in diabetic patients.
What this interaction means in plain words
Diazoxide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diazoxide belongs to Miscellaneous; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Diazoxide opens pancreatic beta-cell potassium channels, suppressing insulin secretion, and also raises catecholamines.
What to do
Avoid the combination where possible. If it is used, monitor blood glucose closely and increase antidiabetic doses as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Diazoxide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diazoxide causes hyperglycemia and directly opposes the glucose-lowering effect of insulin and liraglutide. Glycemic control can deteriorate substantially, sometimes with ketoacidosis in diabetic patients.
How serious is the interaction between Diazoxide and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is used, monitor blood glucose closely and increase antidiabetic doses as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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