Drug interactions
Bendroflumethiazide + Insulin degludec
Severity: Moderate
Bendroflumethiazide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and worsen glycemic control, reducing the effect of insulin degludec. Insulin doses may need to be increased.
What this interaction means in plain words
Bendroflumethiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and insulin resistance reduce glucose tolerance and insulin secretion.
What to do
Monitor blood glucose and potassium after starting bendroflumethiazide. Adjust insulin degludec dose as needed and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Bendroflumethiazide with Insulin degludec?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and worsen glycemic control, reducing the effect of insulin degludec. Insulin doses may need to be increased.
How serious is the interaction between Bendroflumethiazide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting bendroflumethiazide. Adjust insulin degludec dose as needed and correct hypokalemia.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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