Drug interactions
Bendroflumethiazide + Insulin glulisine
Severity: Moderate
Bendroflumethiazide and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin, particularly at higher doses. Patients with diabetes may need an increase in insulin dose.
What this interaction means in plain words
Bendroflumethiazide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity cause hyperglycemia that opposes insulin.
What to do
Monitor blood glucose and serum potassium after starting or changing the thiazide, and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Frequently asked questions
Can I take Bendroflumethiazide with Insulin glulisine?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin, particularly at higher doses. Patients with diabetes may need an increase in insulin dose.
How serious is the interaction between Bendroflumethiazide and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting or changing the thiazide, and adjust the insulin dose as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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