Drug interactions
Insulin glulisine + Rosiglitazone
Severity: Major
Insulin glulisine and Rosiglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone with insulin raises the risk of hypoglycemia and of edema and congestive heart failure. Combined use is generally discouraged because of the cardiovascular fluid-retention risk.
What this interaction means in plain words
Insulin glulisine and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin glulisine belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Rosiglitazone increases insulin sensitivity, adding to insulin effect, and both promote sodium and fluid retention.
What to do
Avoid in patients with heart failure risk and monitor for edema, rapid weight gain and dyspnea. Reduce insulin if hypoglycemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glulisine
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Insulin glulisine with Rosiglitazone?
MediHelp rates the interaction as major. Insulin glulisine and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone with insulin raises the risk of hypoglycemia and of edema and congestive heart failure. Combined use is generally discouraged because of the cardiovascular fluid-retention risk.
How serious is the interaction between Insulin glulisine and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with heart failure risk and monitor for edema, rapid weight gain and dyspnea. Reduce insulin if hypoglycemia occurs.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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