Drug interactions
Bendroflumethiazide + Meloxicam
Severity: Moderate
Bendroflumethiazide and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meloxicam can reduce the diuretic and antihypertensive effect of thiazides. Together they may also raise the risk of reduced renal function, especially with volume depletion.
What this interaction means in plain words
Bendroflumethiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing thiazide effects.
What to do
Monitor blood pressure, fluid status, serum creatinine and electrolytes, especially when starting or changing doses; ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Bendroflumethiazide with Meloxicam?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meloxicam can reduce the diuretic and antihypertensive effect of thiazides. Together they may also raise the risk of reduced renal function, especially with volume depletion.
How serious is the interaction between Bendroflumethiazide and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, serum creatinine and electrolytes, especially when starting or changing doses; ensure adequate hydration.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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